Dermatological Disease Mechanism Research Based on 3Dmicroflu™

CD BioSciences is a biotechnology company dedicated to promoting the high resolution 3Dmicroflu™ 3D bioprinting technology platform and high quality customised bioinks that can be applied to 3D printing organ and tissue micro-models. 3Dmicroflu™ technology platform can provide you with in vitro models that reflect and mimic the characteristics of in vivo dermatological diseases for applications in various types of dermatological disease mechanism research and drug screening. CD BioSciences has experts in the field of 3D bioprinting to offer consultation and services related to dermatological diseases.

The skin is the first physiological line of defense and the largest organ of the body and is constantly involved in the functional activities of the body. The skin is an important barrier in maintaining the health of the body, while maintaining the balance between the internal and external environment of the body. The skin has physiological protection functions, such as barrier, sensory, temperature regulation, absorption, secretion and excretion. When the physiological functions of the skin are compromised, the body has a certain chance of developing skin diseases. Most common dermatological diseases do not affect health, but are contagious, such as leprosy, scabies, fungal diseases, etc. There are also some dermatological diseases that can seriously affect normal life or even threaten life, such as vitiligo, skin cancer, lupus erythematosus, etc. Currently, relevant research hotspots focus on the types of skin diseases that are important to human life and health.

Fig. 1. Hands of the patient with vitiligo skin disease.

Skin models have been an important component of in vitro testing in the process of studying the mechanisms of skin diseases and related drugs. If in vitro construction of models that realistically reflect and recover skin characteristics in the human environment can be achieved, this will greatly facilitate the process of dermatology research.

3Dmicroflu™ in the process of research on dermatological disease mechanisms

The study of dermatological diseases is of certain biological significance, and this process has been a bottleneck regarding the construction of dermatological models. On the one hand, cell-cell interactions in cell culture on a two-dimensional plane cannot fully simulate the cell-cell interactions in three-dimensional skin organs. On the other hand, there are intrinsic differences between animals and humans, which may lead to different characteristics and effects of dermatological models in different organisms. Based on this, CD BioSciences offers a high-resolution and high-throughput 3D printing technology platform called 3Dmicroflu™ for the personalization of in vitro dermatology models. Currently, melanoma models are relatively widely used dermatology models. Of course, if you have other dermatology model customization needs, please get in touch with our 3D bioprinting experts.

Fig. 2. 3Dmicroflu™ technology platform in the process of dermatology model construction.

Using 3Dmicroflu™ technology platform to construct dermatological models for dermatological mechanism studies as well as drug screening tests has the following advantages.

• Realization of complex and highly accurate dermatological model construction
  3Dmicroflu™ is a microfluidic system based single cell printing technology platform. The dermatology models constructed through 3Dmicroflu™ platform reflect and mimic the in vivo complex physiological environment with physiologically relevant structures, including the addition of melanocytes, the generation of skin follicles and the generation of viable skin disorder models.
• Realization of personalized model building and personalized treatment customization
  Personalized medicine is the current trend in biomedicine. As shown in the figure above, 3Dmicroflu™ technology platform enables the construction of personalized dermatology models using the patient's skin cells. Based on the personalized model, you can then perform personalized drug screening and testing. The ultimate goal is to customize dermatological treatments to maximize their effectiveness and minimize side effects.

If you are interested in our high-resolution 3Dmicroflu™ 3D bioprinting technology platform, please contact us now for professional services. All services are available on a 24/7/365 basis.