Fibrotic Disease Mechanism Research Based on 3Dmicroflu™

CD BioSciences is a biotechnology company dedicated to promoting the high resolution 3Dmicroflu™ 3D bioprinting technology platform and high quality customised bioinks that can be applied to 3D printing organ and tissue micro-models. 3Dmicroflu™ technology platform can provide you with the construction of fibrotic disease models to advance your research and drug screening in fibrotic disease mechanisms. CD BioSciences' experts with extensive experience in the field of bio-3D printing are waiting to receive your enquiry.

Tissue fibrosis is a major cause of disability and death in many diseases and plays an important role in the development and progression of disease in all major organs of the body. The main pathological change in fibrosis is an increase in fibrous connective tissue and a decrease in parenchymal cells in organ tissue. The end result of fibrosis is structural destruction, hypofunction and failure of organs. In the diagram below the process of lung injury culminating in lung fibrosis is demonstrated.

Fig. 1. Diagrammatic representation of physiologic and pathologic fibrotic response to lung injury. (Robert, M, S, et al., 2009)

When tissue cells are damaged, they all undergo a degenerative and inflammatory response. If the damage is minimal, the normal parenchymal cells surrounding the damaged cells will proliferate and repair. This repair can fully restore normal structure and function. However, if the injury is large or repeated, the regenerative capacity of the parenchymal cells surrounding the injury may be exceeded. Fibrosis is essentially a repair response to tissue damage, primarily to protect the relative integrity of the tissues and organs. If this repair response is excessive, overpowering and out of control, it can lead to fibrosis of the organ and a decline in organ function.

3Dmicroflu™ in the process of research on tumour mechanisms

Here, CD BioSciences can provide you with 3Dmicroflu™ technological platform to help you with research related to fibrosis disease. As you can see above, once fibrosis has occurred, its damage will be irreversible. It is therefore of great significance to study the pathogenesis of fibrosis and to develop relevant prevention and treatment methods.

Fig. 2. Applications of 3Dmicroflu™ in the construction of fibrotic disease models.

Our experienced team of experts will communicate with you on a one-to-one basis after you place your order and provide you with in vitro fibrotic disease model construction services through 3Dmicroflu™ technology platform after knowing your project requirements. 3Dmicroflu™ allows the construction of conventional and personalized fibro-customized organ models, which are mainly applied around the following aspects.

• More in-depth research on the pathogenic mechanisms of fibrosis
  It is well known that the precise construction of fibrotic organs can better facilitate the study of fibrotic mechanisms. The high resolution 3D printing 3Dmicroflu™ technology platform enables high-precision single cell printing, which is more suitable for detailed and complex printing of fibrotic organs and tissues. Models constructed through 3Dmicroflu™ technology platform allow you to study complex interactions, such as the kinetics of the fibrotic process in the decrease of parenchymal cells or the increase of mesenchymal cells.
• Faster promotion of fibrosis prevention and repair research
  In the face of irreversible fibrosis, it is important to do research on both its prevention and repair methods. High precision custom fibrosis models printed by our high resolution 3Dmicroflu™ technology platform can greatly improve your efficiency by participating in the screening of relevant therapeutic approaches and drug toxicology. The fibrosis models constructed by 3Dmicroflu™ technology platform are able to reproduce and simulate almost realistically the characteristics of human fibrosis, thus reducing unnecessary effort and experimental time loss.

If you are interested in our high-resolution 3Dmicroflu™ 3D bioprinting technology platform, please contact us now for professional services. All services are available on a 24/7/365 basis.

Reference

1. Robert, M, S.; et al. New mechanisms of pulmonary fibrosis. Chest. 2009, 136(5): 1364-1370.