NASH Micro-model 3D Printing Service

CD BioSciences has been a trusted biotechnology company and our services in bio-3D printing have been well-received by our customers. The team of experts from CD BioSciences provides various types of in vitro model construction services based on the high-resolution 3Dmicroflu™ technology platform, covering almost all aspects of life science research. Here, the advantages and applications of the 3Dmicroflu™ technology platform for the construction of non-alcoholic steatohepatitis models are demonstrated below.

Overview of non-alcoholic steatohepatitis

Non-alcoholic steatohepatitis (NASH), also known as metabolic steatohepatitis, is a clinical syndrome with pathological changes similar to alcoholic hepatitis but without a history of excessive alcohol consumption. NASH occurs in the middle-aged population, especially in overweight and obese individuals. NASH is closely related to metabolic disorders such as obesity, insulin resistance, type 2 diabetes, and hyperlipidemia, which is characterized by hepatocellular steatosis with hepatocellular damage and inflammation. In the absence of human intervention and treatment, NASH can progress to liver fibrosis or cirrhosis in later stages.

NASH has become a very common chronic disease condition nowadays and it is very important to achieve control in the early stages to avoid the development of liver fibrosis. Research on the mechanisms related to NASH is an important basis for drug development. CD BioSciences can help you to realize in vitro micro-model construction of NASH by high resolution 3D bioprinting.

3Dmicroflu™ in the construction of NASH micro-models

If you have a research need for the NASH-related project, you can consider the 3D printing technology platform called 3Dmicroflu™ from CD BioSciences. Our experienced experts can assist you in designing and constructing in vitro liver tissue micro-models based on 3Dmicroflu™ technology platform that can meet your project needs for your NASH mechanistic studies and drug development. 3Dmicroflu™ technology platform will better accelerate and advance the process of your NASH-related projects, which could be your best in vitro model building tool and assistant..

Fig. 1. The general process of 3Dmicroflu™ technology platform in applying to NASH model construction.

With the assistance of 3Dmicroflu™ technology platform, you will be able to realize the following NASH-related research.

• Study of the pathogenesis of NASH

3Dmicroflu™ high-resolution technology platform advances mechanistic research by providing micro-models of NASH that can truly reflect physiological characteristics.The study of NASH pathogenesis is the basis for drug development. The discovery of new pathways or receptors also determines the development of new drugs and methods for the treatment of NASH. Therefore, mechanistic studies of NASH are still needed, and any new discoveries will provide help for treatment.

• NASH-related drug development

The NASH micro-models constructed by 3Dmicroflu™ technology platform can facilitate the in vitro high-throughput screening of relevant drugs, which greatly advances the drug development process. Moreover, the in vitro micro-models are more realistic and closer to physiological conditions to avoid unnecessary cost consumption and resource waste.

• Prediction of the probability of liver fibrosis due to NASH

NASH can turn into liver fibrosis when it is severe without therapeutic intervention. Therefore, it is very important to predict the status of NASH and evaluate the effect of drugs. The NASH micro-model based on 3Dmicroflu™  technology platform can assist you in the in vitro simulation and evaluation of this work.

When your experimental project requires the printing of skin aging models, our high-throughput technology platform will be your best choice. If you are interested in 3Dmicroflu™-based vascular models or have a need for custom skin aging models of your experimental projects, please feel free to contact us for customization services. All services are available on a 24/7/365 basis.