Pharmacokinetic Mechanism Study Based on 3Dmicroflu™
CD BioSciences is a cutting-edge biotechnology company committed to providing 3D bioprinted tissue and organ micro-models. With a team of experienced experts and a unique 3D printing technology platform called 3Dmicroflu™, we can provide you with relevant research services covering various life science fields. One of the very important applications of 3Dmicroflu™ technology platform for printing tissue and organ micro-models is drug development, for which pharmacokinetic studies are a very important part.
Overview of pharmacokinetics
Pharmacokinetics is the study of the dynamic changes of the action of drugs in the body, including the absorption, distribution, biochemical conversion and excretion processes of drugs in the body, especially the law of blood concentration changes over time. The metabolism of drugs is related to the age, gender, individual differences and genetic factors of people. With the development of medicinal chemistry and the continuous improvement of human health, the requirements for the pharmacokinetic properties of drugs are getting higher and higher. To judge the application prospect of a drug, it is necessary not only to have strong efficacy and low toxic side effects, but also to have good pharmacokinetic properties. The in vivo metabolism of drugs mainly includes the following four processes.
The drug enters the blood circulation through the site of drug administration, including gastrointestinal drug delivery, injection drug delivery, respiratory drug delivery, and skin mucous membrane drug delivery.
The drug is transferred to the tissues and organs through the blood. Factors affecting drug distribution include plasma protein binding, local organ vascular flow, tissue affinity and physicochemical properties of the drug.
The drug undergoes biotransformation in the liver or gastrointestinal tract through a series of redox reactions catalyzed by enzymes.
The drug or metabolite is excreted out of the body via the kidneys or bile or by breathing.
3Dmicroflu™ in the construction of pharmacokinetic research models
The study of pharmacokinetics is an important part of pharmacology and an important step in the drug development process. Pharmacokinetics is one of the criteria for drug screening and an important reference basis for determining whether a drug has clinical value. At CD BioSciences, 3Dmicroflu™ technology platform can provide you with various in vitro organ and tissue models for pharmacokinetic studies, which can truly reflect the in vivo physiological environment and characteristics. The high-resolution technology based on single-cell printing culture enables the printing of pharmacokinetic models with high precision and detail, which can help you obtain various data for drug concentration curves over time after drug administration. In general, the drug concentration-time curve, shown on the left, reflects and is used to analyze the effects of absorption, distribution metabolism and excretion of drugs and their metabolites in the body.
High-resolution 3D bioprinting is the most prominent advantage of our technology platform. The micro-models that can be printed for pharmacogenetic studies (e.g. micro-liver model, digestive tract model, etc.) can fully demonstrate the characteristics of the physiological environment, which will make your pharmacogenetic studies more informative and meaningful with the data obtained from 3Dmicroflu™ technology platform.
Fig. 1. 3Dmicroflu™ technology platform is involved in the construction of micro-organ models for pharmacokinetic studies.
The figure below shows the various pharmacogenetic study related contents that can be achieved through 3Dmicroflu™ technology platform.
- Drug interaction studies include drug-plasma protein interactions, drug-enzyme interactions, and drug-drug interaction studies during multiple administration, etc.
- Pharmacokinetic studies of chemical drugs (small molecules, polysaccharide macromolecules), biologics, and natural drugs.
- In vitro metabolism studies of different microorganisms.
- Pharmacokinetic studies of various routes of administration, such as oral, injectable, rectal and topical.
If you don't find a match for your project in the conventional pharmacogenetic analysis described above, you don't have to worry about that because our technology platform can print customizable pharmacogenetic models and our experienced team of experts will provide you with a proprietary solution. And if you are interested in 3Dmicroflu™-based pharmacokinetic micro models, please feel free to contact us for customization services. All services are available on a 24/7/365 basis.
For research use only, not intended for any clinical use.
