Tumour Metastasis Micro-model 3D Printing Service

As a trusted 3D bioprinting biotech company, CD BioSciences' experienced team of experts can offer you various types of in vitro model building services based on the high-resolution 3Dmicroflu™ technology platform covering all aspects of life science research. Here, the advantages and applications of 3Dmicroflu™ technology platform in the construction of tumour metastasis models are demonstrated in the following section.

Overview of malignant tumour metastasis

Metastasis of malignant tumours is not only the major cause of cancer death, but also of tumour treatment failure. After a certain period of growth, the invasiveness of malignant tumour will increase, mainly manifested by accelerated growth rate, infiltration ability and distant metastasis ability. Metastasis is the process of malignant tumour cells reaching other parts of the body from the primary site through lymphatic channels, blood vessels or body cavities for further growth. It is an active process that involves multiple steps, including the growth of transformed cells, cell dissociation of solid tumours, invasion of surrounding tissues, penetration into the vasculature, survival and aggregation in the circulation, penetration of the blood vessel wall, entry into surrounding tissues and continued growth, and finally the formation of metastatic cancer.

Fig. 1. Potential approaches for metastasis prevention based on molecular features of metastatic circulating tumour cells. (Menyailo, M, E, et al., 2021)

3Dmicroflu™ in the construction of malignant tumour metastasis models

A team of oncologists from CD BioSciences has determined the optimal culture conditions that can be applied to large-scale and reproducible in vitro 3D models through preliminary basic research, capable of simulating complex in vivo tumour microenvironment features that include relevant tumour markers, cytoplasmic matrices, immunoreactive substances, etc. Compared to the construction of simple 3D spheroid tumour models, malignant tumour metastasis models involve a more complex composition. However, 3Dmicroflu™ technology platform based on high resolution and enabling single cell printing is advantageous in printing complex and detailed 3D structures. It just takes relatively longer time to print compared to simple structures. However, the accuracy and complexity of model construction is higher at the same time.

Fig. 2. The diagram of tumour cell diffusion.

With CD BioSciences' standardized construction process for tumour metastasis models, you can directly choose the cancer cell line and metastasis type that fits your project and leave the rest of the work to be completed by our experienced experts through 3Dmicroflu™ technology platform. In addition, if your proposed project is very specific, you can also work with our team of experts to develop a customized tumour metastasis model.

CD BioSciences can provide you with the following standardized tumour metastasis model construction services for you to choose from.

CD BioSciences has experience in constructing the above mentioned tumour metastasis models based on 3Dmicroflu™ technology platforms. If you are interested in 3Dmicroflu™-based migration models or have custom tumour metastasis model needs for your experimental project, please feel free to contact us for customization services. All services are available on a 24/7/365 basis.

Reference

1. Menyailo, M, E.; et al. Metastasis prevention: focus on metastatic circulating tumour cells. Molecular Diagnosis & Therapy. 2021, 25: 549-562.